Welcome to Frank Lab
We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction.
Recent Publications
Journal: Journal of Molecular Biology
Author: Acosta-Reyes, F.J., Bhattacharjee, S., Gottesman, M. and Frank, J.
[Abstract] 
Book: Single-Particle Cryo-Electron MicroscopyPublisher: World Scientific
Editor: Joachim Frank
Click here to order.
[Description]
Journal: Nature
Author: Sandip Kaledhonkar, et al.
Journal: Proteomics
Author: Vincent R. Gerbasi, et al.
Article: On the damage done to the structure of the T. acidophilum
proteasome by electron radiation
Journal: Protein Science
Author: Jimin Wang, et al.
[Abstract]
Article: Identification of Changing Ribosome Protein Compositions
using Mass Spectrometry
Journal: Proteomics
Author: Parimal Samir, et al.
[Abstract]
Article: Time-Resolved Cryo-electron Microscopy Using a
Microfluidic Chip
Book: Protein Complex Assembly
Author: Sandip Kaledhonkar, et al.
[Abstract]
Article: Three-Dimensional Analysis of Mitochondrial Crista Ultrastructure
in a Patient with Leigh Syndrome by In Situ Cryoelectron Tomography
Journal: iScience
Author: Stephanie E. Siegmund, et al.
[Summary]
Recent News
New paper in The EMBO Journal
July 19, 2022
Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES
The EMBO Journal (2022) e110581https://doi.org/10.15252/embj.2022110581
Here is an annotated abstract:
“Hepatitis C virus mRNA contains an internal ribosome entry site (IRES) that mediates end-independent translation initiation, requiring [only] a subset of eukaryotic initiation factors (eIFs).”
An internal ribosome entry site, abbreviated IRES, is an RNA element that allows for translation initiation in a cap-independent manner, as part...
