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Structural basis for gating and activation of RyR1.

by Amédée des Georges, Oliver B. Clarke, Ran Zalk, Qi Yuan, Kendall J. Condon, Robert A. Grassucci, Wayne A. Hendrickson, Andrew R. Marks, and Joachim Frank.

Several reconstructions, in the range of 3.6 to 4.4A resolution, portray the structures in open and closed states of the channel and provide clues on the mechanisms of activation and gating, which are mediated by long-range allosteric coupling. In contrast, the papers published in Nature last year by us and two other groups show the channel in the closed state.